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KMID : 1007520160250000125
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Food Science and Biotechnology
2016 Volume.25 No. 0 p.125 ~ p.131
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Adipogenesis Inhibitory Effects of Limonium tetragonum in Mouse Bone Marrow Stromal D1 Cells
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Kwon Myeong-Sook
Fatih Karadeniz
Kim Jung-Ae
Seo Young-Wan
Kong Chang-suk
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Abstract
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Unbalanced differentiation of bone marrow cells into adipocytes rather than osteoblasts causes severe bone-related disorders, such as osteoporosis. Natural products that can act against unbalanced differentiation are targeted for development of functional dietary supplements. Limonium tetragonum, a halophyte known for anti-oxidant constituents, was studied for beneficial effects in prevention of adipogenesis of bone marrow stromal D1 cells in vitro. Solvent-partitioned extract fractions of L. tetragonum prevented differentiating D1 cells from accumulating lipids. Expression of the key adipogenic markers PPARγ, SREBP1c, and C/EBPα were inhibited at mRNA and protein levels. Suppressed protein levels of the phosphorylated MAPK-related factors ERK, JNK, and p-38 indicated inhibition of PPARγ pathway-linked adipogenesis in D1 cells. The n-BuOH fraction was the most effective fraction for bioactive substances. L. tetragonum inhibited adipogenesis in D1 bone marrow stromal cells due to the presence of bioactive flavonoids.
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KEYWORD
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adipogenesis, bone marrow, D1 cell, Limonium tetragonum, PPARγ
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